Abstract: Fluorescent proteins(FPs) are derived from marine organisms(e.g. jellyfish, coral etc). They can realize autofluorescence without exogenous substrates. Their roles in modern life science research are very important. Wide applications of fluorescent proteins in flow cytometry include labeling, gene expression tracking, protein localization and cellular dynamics. This article presents fluorescent proteins from basic features, type …
Abstract: HER2 is the transmembrane glycoprotein of epidermal growth factor receptor family, involved in cell proliferation and differentiation. Abnormal expression or mutation is closely related to tumor invasiveness and poor prognosis. This article summarizes HER2 targeted therapy, biological characteristics, signaling pathway and regulatory mechanism. Keywords: HER2 Targeted Therapy, HER2 Protein Function, HER2 Signaling Pathway 1. …
FineTest would like to invite you to visit the company’s booth at CSCB & Biotec-China 2026. CSCB 2026 Location: Binhu International Convention & Exhibition Center, Hefei, Anhui Province, China Date: April 10 – April 11, 2026 Booth No: Hall 3, Booth B84 Biotec-China 2026 Location: Beijing Huanghe Jingdu Conference Center China, The Third Building Date: …
FineTest would like to invite you to visit the company’s booth at Lab Indonesia 2026. Location: Indonesia Convention Exhibition (ICE), BSD City, Indonesia Date: April 15 – April 17, 2026 Booth No: 5C32 Your presence is FineTest’s honor, thank you and welcome!
Abstract: During flow cytometry analysis of immunology, CD45 marker is nearly used in each antibody combination. As the common antigen of leukocytes, CD45 is widely expressed on the surface of hematopoietic derived leukocytes. Roles in differentiating immune cells and non-immune cells are very important. CD45 is the gating marker required for immunophenotype, tumor microenvironment analysis …
Abstract: Fatty liver refers to excessive fat accumulation in the liver, accounting for more than 5% of liver weight. Changes in diet, less exercising and metabolic diseases(e.g. obesity, hypertension, diabetes etc) increase. The incidence of fatty liver disease(FLD) increases annually. FLD has become one of common hepatopathies worldwide. Early symptoms of most patients are not …
Abstract: After data collection, scientific gating strategy for flow cytometry analysis is required to recognize abnormal cell population in the sample. Data analysis include single and multi-parameter analysis. Important roles of gating in selecting target cell population can remove interference. Accurate identification of cellular phenotype and function provides reliable evidence for disease diagnosis and evaluation. …
Abstract: Pulmonary hypertension(PAH) is the pulmonary arteriole disease featured with persistent vasoconstriction, thickening and remodeling. The increased pulmonary vascular resistance causes right heart failure and even death. Normal pulmonary artery pressure is lower than systemic circulation pressure. If mPAP in resting conditions is above 25 mmHg, pulmonary hypertension is definitely diagnosed. Keywords: Pulmonary Hypertension, Increased …
Abstract: Flow cytometry detects cell surface markers(e.g. CD molecules) via fluorescence-labeled antibodies, and is widely applied in typing and functional analysis of immune cells. Besides surface flow cytometry staining, quantitative analysis can be performed for intracellular or nucleus cytokines, functional proteins and DNA content using fixation and permeabilization technology. Membrane permeability of different dyes is …
Abstract: Interleukin-12(IL-12) is mainly produced by monocyte macrophages. IL-12 promotes differentiation of helper T cell into Th1 cell with antitumor activity, and inhibits tumor promotion of Th2 cytokines via improving IFN-γ production and cell immune. IFN-γ mediated anti-angiogenesis plays an important role in immune regulation and antitumor. Roles of IL-12 family members(e.g. IL-12, IL-23, IL-27, …
