FineTest ELISA kit contributes to the research on intermittent fasting by age and gender. The immunoassay is designed to measure Dopamine,Oxytocin and Prolactin level in plasma or brain homogenates.
Article Title: Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
Journal Title: Cell Metabolism
DOI: 10.1016/j.cmi.2025.06.007
IF: 30.9
PMID: 40157367
Abstract: Aging affects reproductive capabilities in males through physiological and behavioral alterations, including endocrine changes and decreased libido. In this study, we investigated the influence of intermittent fasting (IF) on these aging-related declines, using male C57BL/6J mice. Our findings revealed that IF significantly preserved reproductive success in aged mice, not by improving traditional reproductive metrics such as sperm quality or endocrine functions but by enhancing mating behavior. This behavioral improvement was attributed to IF’s ability to counter age-dependent increases in serotonergic inhibition, primarily through the decreased supply of the serotonin precursor tryptophan from the periphery to the brain. Our research underscores the potential of dietary interventions like IF in mitigating age-associated declines in male reproductive health and suggests a novel approach to managing conditions related to reduced sexual desire, highlighting the complex interplay between diet, metabolism, and reproductive behavior.
Keywords: aging, amino acid metabolism, brain, fertility, intermittent fasting, male, reproduction, serotonin, sexual behavior, tryptophan
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| Mouse DA(Dopamine) ELISA Kit(EM1712) | plasma or brain homogenates | Mouse | Dopamine |
| OT(Oxytocin) ELISA Kit(EU2549) | Oxytocin | ||
| Mouse PRL(Prolactin) ELISA Kit(EM0158) | Prolactin |
Validated Image
Figure Source: Cell Metab. 2025 May 6;37(5):1189-1205.e7. doi: 10.1016/j.cmet.2025.03.001. Epub 2025 Mar 28.