Products
SORBS2 antibody
- Product Name
- SORBS2 antibody
- Catalogue No.
- FNab08112
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- sorbin and SH3 domain containing 2
- Alternative Names
- Sorbin and SH3 domain-containing protein 2|Arg-binding protein 2 (ArgBP2)|Arg/Abl-interacting protein 2|Sorbin|SORBS2|ARGBP2|KIAA0777 antibody
- UniProt ID
- O94875
Application
- Tested Applications
- ELISA, IP
- Recommended dilution
- IP: 1:200-1:2000
Validated Images
IP Result of anti-SORBS2 (IP:FNab08112, 4ug; Detection:FNab08112 1:500) with mouse heart tissue lysate 4000ug.
- Background
- Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12(PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
