[Cited FineTest ELISA Kit] Current Research on Thyroid Metabolic Disorder

FineTest ELISA kit contributes to the research on thyroid metabolic disorder. The immunoassay is designed to measure T3 and TSH level in plasma.

Publication Details
Article Title: Lignin-Assisted local release of triiodothyronine in adipose tissue protects mice against obesity and related metabolic disorders
Journal Title: Chemical Engineering Journal
DOI: 10.1016/j.cej.2024.153810
IF: 13.3

Abstract: Lignin is considered a promising carrier for drugs with aromatic structures via co-self-assembly, endowing the composite particles with functional properties for biomedical applications. Triiodothyronine (T3) has exhibited beneficial effects in obesity and obesity-related metabolic disorders by increasing the energy expenditure of adipose tissue; however, excess thyroid hormones may adversely affect various tissues. T3, which contains benzene rings and hydrophilic functional groups, is co-self-assembled with lignin to fabricate composite lignin–triiodothyronine (L-T3) particles using solvent-shifting methods. The dual driving forces of hydrogen bonding and π–π interactions enhance the co-self-assembly tendency of lignin and T3, thereby improving their distributions in the composite particles. L-T3 can be taken up by adipocytes with well controlled particle size. Moreover, a single locally delivered L-T3 dose to the subcutaneous white adipose tissue (sWAT) of mice does not affect mouse plasma T3 levels, but decreases the adipocyte size and increases uncoupling protein (UCP-1) expression in the sWAT of normal diet and short-term high-fat diet (HFD)-fed mice. Notably, L-T3 decreases body and adipose tissue weights in long-term HFD-fed mice. Furthermore, HFD-induced liver steatosis is substantially ameliorated by local delivery of L-T3 to sWAT. These results suggest that local delivery of L-T3 in adipose tissue exhibits protective effects against obesity and related metabolic disorders.

Keywords: Thyroid Metabolic Disorder, Lignin, Triiodothyronine, Self-assembly tendencies, Solvent-shifting methods, Adipose tissue

Immunoassay

Validated Image

Figure Source: Chemical Engineering Journal, 2024 September, doi: 10.1016/j.cej.2024.153810.