[Cited FineTest ELISA Kit] Current Research on Sonodynamic Therapy for Cancer

FineTest ELISA kit contributes to the research on sonodynamic therapy for cancer. The immunoassay is designed to measure IFN-γ level in tumor tissues and serum.

Publication Details
Article Title: Turning Waste into Wealth: A Potent Sono-Immune Strategy Based on Microcystis
Journal Title: Advanced Materials
DOI: 10.1002/adma.202401974
IF: 27.4
PMID: 38889229

Abstract: Currently, sonodynamic therapy (SDT) has limited therapeutic outcomes and immune responses, highlighting the urgent need for enhanced strategies that can stimulate robust and long-lasting antitumor effects. Microcystis, a notorious microalga, reveals the possibility of mediating SDT owing to the presence of gas vesicles (GVs) and phycocyanin (PC). Herein, a nontoxic strain of Microcystis elabens (labeled Me) is developed as a novel agent for SDT because it generates O2 under red light (RL) illumination, while GVs and PC act as cavitation nuclei and sonosensitizers, respectively. Moreover, algal debris is released after ultrasound (US) irradiation, which primes the Toll-like receptor pathway to initiate a cascade of immune responses. This sono-immune strategy inhibits CT26 colon tumor growth largely by promoting dendritic cell (DC) maturation and cytotoxic T-cell activation. After combination with the immune checkpoint blockade (ICB), the therapeutic outcome is further amplified, accompanied by satisfactory abscopal and immune memory effects; the similar potency is proven in the “cold” 4T1 triple-negative breast tumor. In addition, Me exhibits good biosafety without significant acute or chronic toxicity. Briefly, this study turns waste into wealth by introducing sono-immunotherapy based on Microcystis that achieved encouraging therapeutic effects on cancer, which is expected to be translated into the clinic.

Keywords: immune checkpoint blockade, immunotherapy, microalgae, microcystis, sonodynamic therapy

Immunoassay

Validated Image

Figure Source:   Adv Mater. 2024 Jun 18:e2401974. doi: 10.1002/adma.202401974.