FineTest ELISA kit contributes to the research on outer membrane vesicles for vaccine development. The immunoassay is designed to measure sIgA concentration in saliva and vaginal wash.
Publication Details
Article Title: Outer membrane vesicles generated by an exogenous bacteriophage lysin and protection against Acinetobacter baumannii infection
Journal Title: Journal of Nanobiotechnology
DOI: 10.1186/s12951-024-02553-x
IF: 10.2
PMID: 38773507
Abstract: The outer membrane vesicles (OMVs) produced by Gram-negative bacteria can modulate the immune system and have great potentials for bacterial vaccine development. The OMVs prepared by the lysin (LOMVs) from A. baumannii showed better homogeneity, higher protein yield, lower endotoxin content, and lower cytotoxicity compared to the naturally produced OMVs (nOMVs). However, with a single immunization, LOMVs demonstrated better protection than the nOMVs in the pneumonia mouse model. The novel lysin approach provides a superior choice compared to current methods for OMV production, especially for vaccine development.
Keywords: Outer membrane vesicles, Lysin, Acinetobacter baumannii, Immunization, Vaccine Development
Immunoassay
| FineTest Product | Sample | Species | Detection Target |
| Mouse sIgA(Secretory Immunoglobulin A) ELISA Kit(EM1362) | saliva and vaginal wash | Mouse | sIgA |
Validated Image
Figure Source: J Nanobiotechnology. 2024; 22: 273. doi: 10.1186/s12951-024-02553-x