[Cited FineTest Antibody] Current Research on Radiation-induced Heart Disease

FineTest antibody contributes to the research on radiation-induced heart disease. The western blotting is designed to measure SelS in H9C2 cells.

Publication Details
Article Title: Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease
Journal Title: Bioactive Materials
DOI: 10.1016/j.bioactmat.2024.03.034
IF: 18.9
PMID: 38689659

Abstract: Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking. Selenium (Se) is a trace element with excellent antioxidant and immune-modulatory properties. However, its application in heart radioprotection remains challenging. Herein, we developed a novel bioactive Cordyceps militaris-based Se oral delivery system (Se@CM), which demonstrated superior radioprotection effects in vitro against X-ray-induced damage in H9C2 cells through suppressing excessive ROS generation, compared to the radioprotectant Amifostine. Moreover, Se@CM exhibited exceptional cardioprotective effects in vivo against X-ray irradiation, reducing cardiac dysfunction and myocardial fibrosis by balancing the redox equilibrium and modulating the expression of Mn-SOD and MDA. Additionally, Se@CM maintained immuno-homeostasis, as evidenced by the upregulated population of T cells and M2 macrophages through modulation of selenoprotein expression after irradiation. Together, these results highlight the remarkable antioxidant and immunity modulation properties of Se@CM and shed light on its promising application for cardiac protection against IR-induced disease. This research provides valuable insights into developing effective strategies for preventing and managing RIHD.

Keywords: Radiation-induced heart disease, Antioxidant, Selenium, Selenoprotein, Heart protection

Western Blotting

Validated Image

Figure Source: Bioact Mater. 2024 Apr 23:37:393-406. doi: 10.1016/j.bioactmat.2024.03.034.