TNFSF11 antibody

Synonyms:Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF)|Osteoprotegerin ligand (OPGL)|Receptor activator of nuclear factor kappa-B ligand (RANKL)|TNF-related activation-induced cytokine (TRANCE)|Tumor necrosis factor ligand superfamily member 11 antibody, membrane form|Tumor necrosis factor ligand superfamily member 11 antibody, soluble form|TNFSF11|OPGL|RANKL|TRANCE antibody
Catalogue No.:FNab09838Reactivity:Human
Host:MouseTested Application:ELISA, WB
Clonality:monoclonalIsotype:IgG1
  • SPECIFICATIONS
Product Name
TNFSF11 antibody
Catalogue No.
FNab09838
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG1
Clone ID
4F11
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
tumor necrosis factor (ligand) superfamily, member 11
Alternative Names
Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF)|Osteoprotegerin ligand (OPGL)|Receptor activator of nuclear factor kappa-B ligand (RANKL)|TNF-related activation-induced cytokine (TRANCE)|Tumor necrosis factor ligand superfamily member 11 antibody, membrane form|Tumor necrosis factor ligand superfamily member 11 antibody, soluble form|TNFSF11|OPGL|RANKL|TRANCE antibody
UniProt ID
O14788
Observed MW
35 kDa
Application
Tested Applications
ELISA, WB
Recommended dilution
WB: 1:1000-1:5000
Validated Images
Hela cells were subjected to SDS PAGE followed by western blot with FNab09838(RANKL antibody) at dilution of 1:3000
Background
TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.