A375 cells were subjected to SDS PAGE followed by western blot with FNab06937(PTPN23 antibody) at dilution of 1:500
IP Result of anti-PTPN23 (IP:FNab06937, 5ug; Detection:FNab06937 1:500) with HeLa cells lysate 1000ug.
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab06937(PTPN23 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Background
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies(MVBs) via its interaction with the ESCRT-I complex(endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.