Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab10501(TRPM7 antibody) at dilution of 1:1000
Background
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants.