Products
ADAM17-Specific antibody
- Product Name
- ADAM17-Specific antibody
- Catalogue No.
- FNab00139
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ADAM metallopeptidase domain 17
- Alternative Names
- ADAM 17 antibody, ADAM17 antibody, CD156b antibody, cSVP antibody, Snake venom like protease antibody, TACE antibody, TNF alpha convertase antibody, TNF alpha converting enzyme antibody
- UniProt ID
- P78536
- Observed MW
- 29 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab00139(ADAM17-Specific antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab00139(ADAM17-Specific Antibody) at dilution of 1:200
- Background
- The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
