SW40 cells were subjected to SDS PAGE followed by western blot with FNab08389(SUMO1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08389(SUMO1 antibody) at dilution of 1:50
Background
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.