Products
RASGRF1 antibody
- Product Name
- RASGRF1 antibody
- Catalogue No.
- FNab07131
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Ras protein-specific guanine nucleotide-releasing factor 1
- Alternative Names
- CDC25 antibody, GNRP antibody, GRF1 antibody
- UniProt ID
- Q13972
- Observed MW
- 145 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07131( RASGRF1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab07131( RASGRF1 Antibody) at dilution of 1:100
- Background
- The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
