mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab05714(NFU1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain using FNab05714(NFU1 antibody) at dilution of 1:100
Background
This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.