Products
MECP2 antibody
- Product Name
- MECP2 antibody
- Catalogue No.
- FNab05082
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- methyl CpG binding protein 2 (Rett syndrome)
- Alternative Names
- AUTSX3 antibody
- UniProt ID
- P51608
- Observed MW
- 83 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Validated Images
MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with FNab05082(MECP2 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gastric cancer using FNab05082(MECP2 antibody) at dilution of 1:50
- Background
- DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
