Products
MDM2 antibody
- Product Name
- MDM2 antibody
- Catalogue No.
- FNab05077
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Mdm2 p53 binding protein homolog ( Mouse )
- Alternative Names
- ACTFS antibody
- UniProt ID
- Q00987
- Observed MW
- 50 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
HT-29 cells were subjected to SDS PAGE followed by western blot with FNab05077(MDM2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab05077(MDM2 antibody) at dilution of 1:100
- Background
- This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
