Products
KPNA6 antibody
- Product Name
- KPNA6 antibody
- Catalogue No.
- FNab04638
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- karyopherin alpha 6 (importin alpha 7)
- Alternative Names
- IPOA7 antibody
- UniProt ID
- O60684
- Observed MW
- 60 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab04638( KPNA6 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human kidney using FNab04638( KPNA6 Antibody) at dilution of 1:100 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.
