mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab04289( ILK Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain using FNab04289( ILK Antibody) at dilution of 1:100 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Background
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants.