Products
FAS/CD95 antibody
Category:
Research Area:
Synonyms: | ALPS1A antibody, APO 1 antibody, Apo 1 antigen antibody, APT1 antibody, CD95 antibody, FAS antibody, FAS1 antibody, FASLG receptor antibody, FASTM antibody, TNFRSF6 antibody | ||
Catalogue No.: | FNab03016 | Reactivity: | Human, Mouse, Rat |
Host: | Rabbit | Tested Application: | ELISA, WB, IHC |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- FAS/CD95 antibody
- Catalogue No.
- FNab03016
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Fas (TNF receptor superfamily, member 6)
- Alternative Names
- ALPS1A antibody, APO 1 antibody, Apo 1 antigen antibody, APT1 antibody, CD95 antibody, FAS antibody, FAS1 antibody, FASLG receptor antibody, FASTM antibody, TNFRSF6 antibody
- UniProt ID
- P25445
- Observed MW
- Refer to figures
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab03016(FAS antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03016(FAS antibody) at dilution of 1:100
- Background
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.