Products
DKK1 antibody
- Product Name
- DKK1 antibody
- Catalogue No.
- FNab02401
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- dickkopf homolog 1
- Alternative Names
- Dickkopf 1 antibody, Dickkopf related protein 1 antibody, DKK 1 antibody, DKK1 antibody, hDkk 1 antibody, SK antibody
- UniProt ID
- O94907
- Observed MW
- 30-35 kDa
Application
- Tested Applications
- ELISA, WB, IF, IHC
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab02401(DKK1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab02401(DKK1 Antibody) at dilution of 1:200
Immunofluorescent analysis of HepG2 cells, using DKK1 antibody FNab02401 at 1:25 dilution
- Background
- Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
