Products
DDB1 antibody
- Product Name
- DDB1 antibody
- Catalogue No.
- FNab02284
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- damage-specific DNA binding protein 1, 127kDa
- Alternative Names
- DDB p127 subunit antibody, DDB1 antibody, DDBA antibody, DNA damage binding protein 1 antibody, DNA damage binding protein a antibody, HBV X associated protein 1 antibody, UV damaged DNA binding factor antibody, UV DDB 1 antibody, UV antibody
- UniProt ID
- Q16531
- Observed MW
- 127 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02284(DDB1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver using FNab02284(DDB1 antibody) at dilution of 1:50
- Background
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
