Products
AMPK beta 2 antibody
- Product Name
- AMPK beta 2 antibody
- Catalogue No.
- FNab00378
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- protein kinase, AMP-activated, beta 2 non-catalytic subunit
- Alternative Names
- AMPK beta 2 antibody, AMPK subunit beta 2 antibody, PRKAB2 antibody
- UniProt ID
- O43741
- Observed MW
- 35 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
human brain tissue were subjected to SDS PAGE followed by western blot with FNab00378(PRKAB2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab00378(PRKAB2 antibody) at dilution of 1:100
- Background
- The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
