human liver tissue were subjected to SDS PAGE followed by western blot with FNab02406(DLD antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver injury using FNab02406(DLD antibody) at dilution of 1:100
Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants.