Abstract: Rapid antigen antibody test plays an important role in screening SARS-CoV-2 and also coordinates with nucleic acid testing in early testing for suspected patients suffering from COVID-19. Thus, infection sources can be controlled by the subsequent large-scale screening in the shortest time.
Keywords: Rapid Antigen Antibody Test, SARS-CoV-2, Colloidal Gold Antigen Test, IgG IgM Antibody Test
1. FineTest Products for Rapid Test Production
FineTest can offer sufficient raw materials for producing rapid testing products, including SARS-CoV-2 N protein and relevant monoclonal antibodies for research use. COVID-19 colloidal gold antigen test use rabbit monoclonal antibodies(FNab10600 & FNab10601) with high specificity and affinity.
2. IgG IgM Antibody Test
Antibody detection targets are IgG and IgM. Colloidal gold assay for IgG/IgM is illustrated in the following figure.
3. S Protein Products
Nucleic acid and protein shell are key components of the virus. They can reproduce and protect heredity substance of offspring respectively. Spike glycoprotein(hereafter S protein) can bind with relevant receptors of human cells. Hence, it's the main target of neutralizing antibodies after infection and also plays an important role in the treatment and vaccine design.
A list of FineTest S protein products:
- 【P3006】Recombinant SARS-CoV-2 Spike Glycoprotein RBD
- 【P3018】Recombinant SARS-CoV-2 Spike Glycoprotein
- 【FNab10400】anti- 2019 nCOV S1 protein antibody
- 【FNab10528】anti- 2019 nCOV S1 protein antibody
4. N Protein Products
N protein and virus genomic RNA coil around each other to form virus nucleocapsid, which functions in viral RNA synthesis. Meanwhile, the relatively conserved N protein takes the maximum proportion in structural protein. The organism can produce high level antibody against N protein during early infection. N protein can be used in 2019-nCoV rapid test for serum antibody.
A list of FineTest N protein products:
- 【P3003】Recombinant SARS-CoV-2 Nucleoprotein
- 【P2908】Recombinant SARS-CoV-2 Nucleoprotein [Delta B.1.617.2]
- 【FNab10600】anti- 2019 nCOV N protein antibody (Rabbit mAb, Capture)
- 【FNab10601】anti- 2019 nCOV N protein antibody (Rabbit mAb, Colloidal Gold Labeled)
5. Rapid Test Applications
- Patients with early COVID-19 symptoms in 5 days;
- Isolated patients under observation;
- COVID-19 home test
REFERENCES
[1] Clinical Application of a New SARS-CoV-2 Antigen Detection Kit (Colloidal Gold) in the Detection of COVID-19, PMID: 34070844.
[2] Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test, PMID: 32330303.