[Cited FineTest ELISA Kit] Current Research on Drug Therapy

FineTest ELISA kit contributes to the research on drug therapy. The immunoassay is designed to measure GLP-1 concentration in serum.

Publication Details
Article Title: Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner
Journal Title: Cell Metabolism
DOI: 10.1016/j.cmet.2023.12.027
IF: 29
PMID: 38325336

Abstract: Statins are currently the most common cholesterol-lowering drug, but the underlying mechanism of statin-induced hyperglycemia is unclear. To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients with atorvastatin and 10 controls, followed up for 16 weeks, and found a decreased abundance of the genus Clostridium in feces and altered serum and fecal bile acid profiles among patients with atorvastatin therapy. Animal experiments validated that statin could induce glucose intolerance, and transplantation of Clostridium sp. and supplementation of ursodeoxycholic acid (UDCA) could ameliorate statin-induced glucose intolerance. Furthermore, oral UDCA administration in humans alleviated the glucose intolerance without impairing the lipid-lowering effect. Our study demonstrated that the statin-induced hyperglycemic effect was attributed to the Clostridium sp.-bile acids axis and provided important insights into adjuvant therapy of UDCA to lower the adverse risk of statin therapy.

Keywords: Drug Therapy, Clostridium, GLP-1, UDCA, glucose intolerance, statin

Immunoassay

Illustration

Figure Source: Cell Metab. 2024 Feb 6;36(2):408-421.e5. doi: 10.1016/j.cmet.2023.12.027.