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SARS-CoV-2 Related Antibodies and Proteins

Abstract:         Since the outbreak of SARS-CoV-2, there are many variants. FineTest has developed some SARS-CoV-2 related antibodies and proteins for research use only.
Keywords:      SARS-CoV-2, COVID-19, Anti Spike Antibodies, Nucleocapsid Antibodies, Spike Protein, Spike Glycoprotein, Nucleoprotein

1. Overview of SARS-CoV-2

SARS-CoV-2 is a RNA virus which has a high mutation frequency of about three per million during virus replication. In other words, one in every 10 viruses may mutate. Thus, the appearance of new variant is normal.

Based on the criticality, variants of SARS-CoV-2 are classified as two types by WHO: variant of concern(VOC) and variant of interest (VOI). VOC causes many SARS-CoV-2 cases in the world and many data have shown its transmissibility, strong toxicity and reduction of curative effect in vaccine or clinical treatment. VOI causes community cases or appears in many countries. But mass infection doesn't appear. Currently, VOC has a great influence and threat on epidemic situation, including Alpha, Beta, Gamma, Delta, Omicron.

2. Omicron Variant(B.1.1.529)

In 2021, Omicron (B.1.1.529) is initially detected in a South African case sample. The variant has a rapid increase in two weeks and is identified as the variant of concern(VOC) by WHO. See the comparison of mutation sites between five variants.

SARS-CoV-2 Variant: antibodies and proteins

Figure Source: Zoonoses, 2021, DOI: 10.15212/ZOONOSES-2021-0024.

There are 50 mutations in B.1.1.529. Spike protein has 32 mutations. It's reported that the mutation of Omicron is twice as Delta. Especially, H655Y, N679K and P681H can easily help virus enter human body.

Omicron vs Delta

Figure Source: COVID-19 Genomics UK (COG-UK) Consortium.

3. FineTest SARS-CoV-2 Antibodies and Proteins

Nucleoprotein Products
P3003 Recombinant SARS-CoV-2 Nucleoprotein
P2908 Recombinant SARS-CoV-2 Nucleoprotein [Delta B.1.617.2]
P8341 Recombinant SARS-CoV-2 Nucleoprotein [Omicron B.1.1.529]
FNab10308 anti- 2019 nCOV N protein antibody
FNab10309 anti- 2019 nCOV N protein antibody
Spike Proteins Products
P3006 Recombinant SARS-CoV-2 Spike Glycoprotein RBD
P3018 Recombinant SARS-CoV-2 Spike Glycoprotein
P8342 Recombinant SARS-CoV-2 Spike Glycoprotein RBD [Omicron B.1.1.529]
FNab10400 anti- 2019 nCOV S1 protein antibody
FNab10528 anti- 2019 nCOV S1 protein antibody

REFERENCES

[1] Mechanisms of SARS-CoV-2 Transmission and Pathogenesis, PMID: 33132005.
[2] From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses, PMID: 32798769.