Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine(PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules(By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification(PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay(By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating(By similarity).
