Products
XIAP antibody
- Product Name
- XIAP antibody
- Catalogue No.
- FNab09540
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- X-linked inhibitor of apoptosis
- Alternative Names
- API3 antibody, BIRC4 antibody, hIAP 3 antibody, hIAP3 antibody, hILP antibody, IAP 3 antibody, IAP like protein antibody, IAP3 antibody, ILP antibody, ILP1 antibody, MIHA antibody, X linked IAP antibody, XIAP antibody, XLP2 antibody
- UniProt ID
- P98170
- Observed MW
- 54 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09540(XIAP antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas cancer using FNab09540(XIAP antibody) at dilution of 1:200
Immunofluorescent analysis of (4% PFA) fixed HeLa cells using FNab09540 (XIAP antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti- apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
