BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab09321(USP25 antibody) at dilution of 1:1000
immunohistochemistry of paraffin-embedded mouse heart using FNab09321(USP25 antibody) at dilution of 1:100
Background
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).