anti- USP20 antibody

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Product Information
Product name

anti- USP20 antibody

Alternative name

KIAA1003 antibody, LSFR3A antibody, VDU2 antibody, USP20 Antibody

Catalogue No.

FNab09317

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Description

USP20 antibody: Rabbit Polyclonal antibody to USP20

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) . Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both ‘Lys-48’-and ‘Lys-63’-linked polyubiquitin chains.

Immunogen Information
Immunogen

ubiquitin specific peptidase 20

Synonyms

Deubiquitinating enzyme 20, hVDU2, KIAA1003, LSFR3A, Ubiquitin thiolesterase 20, USP20, VDU2

Calculated MW

68 kDa

Application
Specificity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:200-1:2000; IHC: 1:20-1:200;IP: 1:200-1:2000

Uniprot information
Gene Name

USP20

Uniprot ID

Q9Y2K6

Images

anti- USP20 antibody 1

Immunohistochemistry of paraffin-embedded human kidney using FNab09317 (USP20 antibody) at dilution of 1:50


anti- USP20 antibody 1

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09317 (USP20 antibody) at dilution of 1:400

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027-87384275
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