anti- TRAIP antibody

  • Specifications
  • Manual
  • Contact
Product Information
Product name

anti- TRAIP antibody

Alternative name

RNF206 antibody, TRIP antibody, TRAIP Antibody

Catalogue No.

FNab08924

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Description

TRAIP antibody: Rabbit Polyclonal antibody to TRAIP

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting ‘Lys-48’-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of ‘Lys-63’-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

Immunogen Information
Immunogen

TRAF interacting protein

Synonyms

RNF206, TRIP

Calculated MW

53 kDa

Application
Specificity

Human, Mouse

Tested Application

ELISA, WB, IHC, IF

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Uniprot information
Gene Name

TRAIP

Uniprot ID

Q9BWF2

Images

anti- TRAIP antibody 1

Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08924(TRAIP Antibody) at dilution of 1:200


anti- TRAIP antibody 1

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab08924(TRAIP antibody) at dilution of 1:1000

Current product's manual: Manual

Protocol may be updated. Please feel free to contact Finetest Team to acquire the latest version.

RetailerEnd User





RetailerEnd User





Service

Hotline

027-87384275
var cnzz_s_tag=document.createElement('script'); cnzz_s_tag.type='text/javascript'; cnzz_s_tag.async=true; cnzz_s_tag.charset='utf-8'; cnzz_s_tag.src='https://w.cnzz.com/c.php?id=1253658600&async=1'; var root_s=document.getElementsByTagName('script')[0]; root_s.parentNode.insertBefore(cnzz_s_tag,root_s);