MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab08919(TRAF4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human heart tissue slide using FNab08919(TRAF4 antibody) at dilution of 1:50
Immunofluorescence analysis of A549 cells using FNab08919(TRAF4 antibody).
Background
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.