Products

TGF-beta 3 antibody

Synonyms:ARVD antibody, ARVD1 antibody, LDS5 antibody, RNHF antibody, TGF-beta3 antibody
Catalogue No.:FNab08640Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
TGF-beta 3 antibody
Catalogue No.
FNab08640
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
transforming growth factor, beta 3
Alternative Names
ARVD antibody, ARVD1 antibody, LDS5 antibody, RNHF antibody, TGF-beta3 antibody
UniProt ID
P10600
Observed MW
45KD
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
K-937 cells were subjected to SDS PAGE followed by western blot with FNab08640(TGFB3 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse ovary using FNab08640(TGFB3 antibody) at dilution of 1:100
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1.