HeLa cells were subjected to SDS PAGE followed by western blot with FNab08549(TCEB2 antibody) at dilution of 1:1000
IP Result of anti-TCEB2 (IP:FNab08549, 4ug; Detection:FNab08549 1:500) with HEK-293 cells lysate 3200ug.
Immunohistochemistry of paraffin-embedded human colon cancer using FNab08549(TCEB2 antibody) at dilution of 1:100
Background
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.