Products
TCEB1 antibody
- Product Name
- TCEB1 antibody
- Catalogue No.
- FNab08548
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
- UniProt ID
- Q15369
- Observed MW
- 13 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab08548(TCEB1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab08548(TCEB1 antibody) at dilution of 1:50
- Background
- This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.
