HeLa cells were subjected to SDS PAGE followed by western blot with FNab08434(SYNCRIP antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver cancer using FNab08434(SYNCRIP antibody) at dilution of 1:100
Immunofluorescence analysis of MCF-7 cells using FNab08434(SYNCRIP antibody). Blue: DAPI for nuclear staining.
Background
This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20.