human placenta tissue were subjected to SDS PAGE followed by western blot with FNab08153(SPARC antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer using FNab08153(SPARC antibody) at dilution of 1:100
Background
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.