Products
SMC1A antibody
- Product Name
- SMC1A antibody
- Catalogue No.
- FNab08016
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- structural maintenance of chromosomes 1A
- Alternative Names
- DXS423E antibody, KIAA0178 antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody
- UniProt ID
- Q14683
- Observed MW
- 143-150 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500 - 1:2000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08016(SMC1A antibody) at dilution of 1:1000
Immunofluorescence analysis of U2OS cells using FNab08016(SMC1A antibody) at dilution of 1:50
- Background
- Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
