Products

SMARCA4 antibody

Synonyms:BAF190A antibody, BRG1 antibody, SNF2B antibody, SNF2L4 antibody
Catalogue No.:FNab08004Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
SMARCA4 antibody
Catalogue No.
FNab08004
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Alternative Names
BAF190A antibody, BRG1 antibody, SNF2B antibody, SNF2L4 antibody
UniProt ID
P51532
Observed MW
180 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:50
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08004(SMARCA4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon using FNab08004( SMARCA4 Antibody) at dilution of 1:50
Background
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.