HeLa cells were subjected to SDS PAGE followed by western blot with FNab07877( SIRT1 Antibody) at dilution of 1:1000
IP Result of anti-SIRT1 (IP:FNab07877, 4ug; Detection:FNab07877 1:500) with mouse testis tissue lysate 8000ug.
Immunohistochemistry of paraffin-embedded mouse testis tissue slide using FNab07877( SIRT1 Antibody) at dilution of 1:100
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.