Products

SIRT1 antibody

Synonyms:hSIR2 antibody, hSIRT1 antibody, SIR2 like protein 1 antibody, SIR2L1 antibody, SIRT1 antibody
Catalogue No.:FNab07877Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
SIRT1 antibody
Catalogue No.
FNab07877
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
sirtuin (silent mating type information regulation 2 homolog) 1
Alternative Names
hSIR2 antibody, hSIRT1 antibody, SIR2 like protein 1 antibody, SIR2L1 antibody, SIRT1 antibody
UniProt ID
Q96EB6
Observed MW
130 kDa
Application
Tested Applications
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab07877( SIRT1 Antibody) at dilution of 1:1000
IP Result of anti-SIRT1 (IP:FNab07877, 4ug; Detection:FNab07877 1:500) with mouse testis tissue lysate 8000ug.
Immunohistochemistry of paraffin-embedded mouse testis tissue slide using FNab07877( SIRT1 Antibody) at dilution of 1:100
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.