HeLa cells were subjected to SDS PAGE followed by western blot with FNab07851(SHMT2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab07851(SHMT2 antibody) at dilution of 1:100
Background
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5, 10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.