anti- RPS3 antibody

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Product Information
Product name

anti- RPS3 antibody

Alternative name

RPS3 Antibody

Catalogue No.

FNab07477

Size

100µg

Form

liquid

Purification

Protein A+G purification

Purity

≥95% as determined by SDS-PAGE

Host

Mouse

Clonality

Monoclonal

Isotype

IgG1

Description

RPS3 antibody: Mouse Monoclonal antibody to RPS3

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Involved in translation as a component of the 40S small ribosomal subunit(PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA(PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA(PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine(8-oxoG), a common DNA lesion caused by reactive oxygen species(ROS)(PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA(PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1(PubMed:15518571). Enhances the uracil excision activity of UNG1(PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1(PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage(PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide(PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes(PubMed:18045535). Represses its own translation by binding to its cognate mRNA(PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination(PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization(PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8(PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5(PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation(PubMed:22510408).

Immunogen Information
Immunogen

ribosomal protein S3

Synonyms

40S ribosomal protein S3, ribosomal protein S3, RPS3

Calculated MW

33 kDa

Application
Specificity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF, IP

Recommended dilution

WB: 1:10000-1:50000; IP: 1:1000-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

Uniprot information
Gene Name

RPS3

Uniprot ID

P23396

Images

anti- RPS3 antibody 1

Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab07477(RPS3 Antibody) at dilution of 1:100 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).


anti- RPS3 antibody 1

RAW 264.7 cells were subjected to SDS PAGE followed by western blot with FNab07477(RPS3 Antibody) at dilution of 1:8000

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