anti- POLR1A antibody
Immunogen affinity purified
≥95% as determined by SDS-PAGE
POLR1A antibody: Rabbit Polyclonal antibody to POLR1A
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity) .
polymerase (RNA) I polypeptide A, 194kDa