HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06574(PMM2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate using FNab06574( PMM2 Antibody) at dilution of 1:100 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Background
The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I.