Products

PIAS4 antibody

Synonyms:E3 SUMO protein ligase PIAS4 antibody, PIAS gamma antibody, PIAS4 antibody, Piasg antibody, PIASY antibody, ZMIZ6 antibody
Catalogue No.:FNab06432Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
PIAS4 antibody
Catalogue No.
FNab06432
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
protein inhibitor of activated STAT, 4
Alternative Names
E3 SUMO protein ligase PIAS4 antibody, PIAS gamma antibody, PIAS4 antibody, Piasg antibody, PIASY antibody, ZMIZ6 antibody
UniProt ID
Q8N2W9
Observed MW
60 kDa
Application
Tested Applications
ELISA, WB, IF
Recommended dilution
WB: 1:500-1:2000; IF: 1:50-1:500
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab6432(PIAS4 antibody) at dilution of 1:500
Background
Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.