Products
PEX5 antibody
- Product Name
- PEX5 antibody
- Catalogue No.
- FNab06331
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- peroxisomal biogenesis factor 5
- Alternative Names
- FLJ50634 antibody, FLJ50721 antibody, FLJ51948 antibody, Peroxin 5 antibody, Peroxisome receptor 1 antibody, PEX5 antibody, PTS1 BP antibody, PTS1 receptor antibody, PTS1R antibody, PXR1 antibody
- UniProt ID
- P50542
- Observed MW
- 70 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
SW480 cells were subjected to SDS PAGE followed by western blot with FNab06331(PEX5 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse kidney tissue slide using FNab06331( PEX5 Antibody) at dilution of 1:100
Immunofluorescence analysis of HeLa cells using FNab06331( PEX5 Antibody). Blue: DAPI for nuclear staining.
- Background
- The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
