mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab06311(PER1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab06311( PER1 Antibody) at dilution of 1:100
Background
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.