mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab06242(PDCD6 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach cancer using FNab06242(PDCD6 antibody) at dilution of 1:100
Background
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.