Products
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OGG1 antibody
- Product Name
- OGG1 antibody
- Catalogue No.
- FNab05980
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- 8-oxoguanine DNA glycosylase
- Alternative Names
- MMH antibody, MUTM antibody, OGH1 antibody
- UniProt ID
- O15527
- Observed MW
- 36 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab05980( OGG1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain using FNab05980(OGG1 antibody) at dilution of 1:100
- Background
- This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
