Products
MICAL2 antibody
- Product Name
- MICAL2 antibody
- Catalogue No.
- FNab05178
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- microtubule associated monoxygenase, calponin and LIM domain containing 2
- Alternative Names
- KIAA0750 antibody, MICAL2PV1 antibody, MICAL2PV2 antibody
- UniProt ID
- O94851
- Observed MW
- 95, 112 kDa
Application
- Tested Applications
- ELISA, IHC, IF
- Recommended dilution
- IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
Immunohistochemistry of paraffin-embedded human stomach cancer slide using FNab05178(MICAL2 Antibody) at dilution of 1:50
- Background
- Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
